Safety considerations in the management of allergic diseases: focus on antihistamines
Kazuhiko Yanai, B. Rogala, K. Chugh, E. Paraskakis, A. N. Pampura, R. Boev•April 1, 2012•68 citations
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Abstract
Second-generation oral antihistamines are the preferred first-line treatment option for allergic rhinitis and urticaria. Patients taking SGAHs report relatively little and mild adverse events even after long-term continuous treatments. An antihistamine should ideally possess high selectivity for the H(1)-receptor, high PrH1R occupancy and low to no BrH1R occupancy.