Frontiers in Skin Rejuvenation: Recent Advances in Anti-Aging Skincare Technologies Based on Proteins, Peptides, and Peptide Derivatives

Zhongyi Mao • 3/4/2025

Abstract

Skin aging, characterized by collagen and elastin degradation, reduced cellular turnover, and oxidative stress, leads to wrinkles, sagging, and uneven skin tone. The global anti-aging skincare market is projected to reach $421.4 billion by 2030, driven by the demand for innovative solutions. Proteins, peptides, and peptide derivatives have emerged as key ingredients in modern anti-aging skincare due to their ability to stimulate collagen synthesis, enhance hydration, and repair damaged skin. Peptide derivatives like acetyl hexapeptide-8 (Argireline) and palmitoyl pentapeptide-4 (Matrixyl) have been clinically proven to reduce wrinkles and improve skin elasticity. Advanced technologies, such as nanotechnology and AI-driven formulations, enhance peptide stability and efficacy. The integration of peptides with stem cells and microbiome modulation offers comprehensive anti-aging solutions, while personalized skincare based on genetic profiling enables tailored treatments.The future of anti-aging skincare lies in sustainable and ethical practices, including plant-based peptides and eco-friendly packaging. These advancements promise to revolutionize the industry, delivering effective, personalized, and environmentally responsible solutions for skin rejuvenation.

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